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Topographic Rod Recovery Profiles after a Prolonged Dark Adaptation in Subjects with Reticular Pseudodrusen

Published:August 18, 2018DOI:https://doi.org/10.1016/j.oret.2018.06.016

      Purpose

      Although rod function is known to be severely impaired in eyes with reticular pseudodrusen (RPD), it remains unknown whether this impairment is associated with a total loss of rod function or merely a delay in rod recovery. The purpose of the study was to determine rod functional recovery profiles after prolonged dark adaptation (DA) in eyes with age-related macular degeneration (AMD) and RPD.

      Design

      A cross-sectional, case-series study.

      Participants

      Subjects with AMD and RPD.

      Methods

      Retinal sensitivity was assessed simultaneously at 14 retinal locations within the central 12° in the study eye of each subject after the eye received approximately 20% bleach. Recovery of retinal sensitivity was monitored at regular intervals up to 30 minutes after bleach. If retinal sensitivity of all test points had not recovered to the rod criterion level (−3.0 log units of stimulus intensity) after 30 minutes of DA, monitoring recovery of retinal sensitivity was extended up to 24 hours of DA.

      Main Outcome Measures

      Rod functional recovery profile at each test point.

      Results

      Six AMD cases with RPD were included, aged 69 to 79 years, and visual acuity ranged from 20/20 to 20/25. All cases had a delay in rod functional recovery at many retinal locations, with test points within the central 6° most affected. The recovery rate was variable between retinal loci and between subjects, although RPD were present at all test locations. In 5 cases with stage 3 RPD, rod function recovered at all tested locations, but many locations took hours to do so. The case with stage 4 RPD had locations that failed to recover even after 24 hours of DA.

      Conclusions

      Eyes with AMD and RPD are associated with severe rod dysfunction throughout the macula; however, rod function does recover in most cases after an extended DA time. These findings suggest that the delay in rod recovery in eyes with RPD is, in most cases, associated with the impairment rather than the total loss of rod photoreceptor function. Stage 4 RPD may represent a point at which some rod photoreceptors are nonfunctional.

      Abbreviations and Acronyms:

      AMD (age-related macular degeneration), BCVA (best-corrected visual acuity), BM (Bruch’s membrane), DA (dark adaptation), DACP (dark-adapted chromatic perimeter), FAF (fundus autofluorescence), iAMD (intermediate age-related macular degeneration), IS/OS (inner segment and outer segment), LLVA (low luminance visual acuity), MMI (multimodal imaging), NIR (near infrared reflectance), ONL (outer nuclear layer), RPD (reticular pseudodrusen), RPE (retinal pigment epithelium), SD-OCT (spectral-domain optical coherence tomography), SFD (Sorsby’s fundus dystrophy)
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